Vitamin D and viral infections: Infectious diseases, autoimmune diseases, and cancers

Adv Food Nutr Res. 2024:109:271-314. doi: 10.1016/bs.afnr.2023.12.007. Epub 2024 Mar 2.

Abstract

Viruses can cause many human diseases. Three types of human diseases caused by viruses are discussed in this chapter: infectious diseases, autoimmune diseases, and cancers. The infectious diseases included in this chapter include three respiratory tract diseases: influenza, COVID-19, and respiratory syncytial virus. In addition, the mosquito-borne dengue virus diseases are discussed. Vitamin D can reduce risk, severity, and mortality of the respiratory tract diseases and possibly for dengue virus. Many autoimmune diseases are initiated by the body's reaction to a viral infection. The protective role of vitamin D in Epstein-Barr virus-related diseases such as multiple sclerosis is discussed. There are a few cancers linked to viral infections. Such cancers include cervical cancer, head and neck cancers, Hodgkin's and non-Hodgkin's lymphoma, and liver cancer. Vitamin D plays an important role in reducing risk of cancer incidence and mortality, although not as strongly for viral-linked cancers as for other types of cancer.

Keywords: Autoimmune diseases; COVID-19; Cancers; Dengue virus; Epstein-Barr virus; Human papillomavirus; Immune system; Influenza; Multiple sclerosis; Respiratory syncytial virus; SARS-CoV-2; Ultraviolet B; Vitamin D.

Publication types

  • Review

MeSH terms

  • Autoimmune Diseases*
  • COVID-19* / prevention & control
  • Communicable Diseases
  • Humans
  • Neoplasms*
  • SARS-CoV-2
  • Virus Diseases*
  • Vitamin D*

Substances

  • Vitamin D