RAMPing up knowledge of the translocon

Elife. 2024 May 24:13:e98548. doi: 10.7554/eLife.98548.

Abstract

Advanced cryo-EM approaches reveal surprising insights into the molecular structure that allows nascent proteins to be inserted into the membrane of the endoplasmic reticulum.

Keywords: RAMP4; Sec61; cell biology; cryo-EM; molecular biophysics; multipass translocon; none; ribosomes; structural biology.

Publication types

  • Editorial

MeSH terms

  • Cryoelectron Microscopy*
  • Endoplasmic Reticulum* / metabolism
  • Membrane Proteins / chemistry
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism
  • Protein Transport*

Substances

  • Membrane Proteins