Global trends in oxidative stress in the Retina: A bibliometric analysis of 2013-2023

Meng Xiong; Chang Yu; Baoping Ren; Meiqi Zhong; Jing Lu; Chengzhi Yuan; Qifang Sun; Qinghua Peng; Meiyan Zeng; Houpan Song

doi:10.1016/j.heliyon.2024.e31620

Global trends in oxidative stress in the Retina: A bibliometric analysis of 2013-2023

Heliyon. 2024 May 21;10(10):e31620. doi: 10.1016/j.heliyon.2024.e31620. eCollection 2024 May 30.

Authors

Meng Xiong^{1

2}, Chang Yu^{1

2}, Baoping Ren^{1

2}, Meiqi Zhong^{1

2}, Jing Lu^{3

4}, Chengzhi Yuan^{1

4}, Qifang Sun^{1

2}, Qinghua Peng³, Meiyan Zeng², Houpan Song^{1

2

3}

Affiliations

¹ Hunan Provincial Key Laboratory of Traditional Chinese Medicine Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan, China.
² School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, China.
³ Hunan Provincial Key Laboratory for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, China.
⁴ School of Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, China.

Abstract

Background: Oxidative stress plays a significant role in the pathogenesis of many retinal diseases. However, only a few systematic bibliometric studies have been conducted. This study aims to visualize research hotspots and developmental trends in oxidative stress in the retina from 2013 to 2023 by analyzing bibliometric data.

Methods: We retrieved papers on oxidative stress in the retina published between 2013 and 2023 from the Web of Science Core Collection. The data were visually analyzed using CiteSpace and VOSviewer software.

Results: The total number of 2100 publications were included in the analysis. An overall increasing trend in the number of publications is observed between 2013 and 2023. Chinese publications were the most contributive, but United States publications were the most influential. Shanghai Jiao Tong University was the most active and prolific institution. Antioxidants was the most productive journal, while Oxidative Medicine and Cellular Longevity were the journals with the most-cited articles. Kaarniranta K, from Finland, was the most productive and influential author. Examination of co-cited references revealed that researchers in the field are primarily focused on investigating the molecular mechanisms, preventive strategies, and utilization of antioxidants to address retinal oxidative damage. Diabetic retinopathy, endothelial growth factor, retinitis pigmentosa, retinal degeneration, antioxidant response, retinal ganglion cells, and genes are the research hotspots in this field. Metabolism, sodium iodate, and system are at the forefront of research in this field.

Conclusion: Attention toward retinal oxidative stress has increased over the past decade. Current research focuses on the mechanisms of retinal diseases related to oxidative stress and the experimental study of antioxidants in retinal diseases, which may continue to be a trend in the future.

Keywords: Age-related macular degeneration; Bibliometric analysis; Diabetic retinopathy; Oxidative stress; Retina; Retinitis pigmentosa.