Exploring real-world vancomycin target attainment in neonatal intensive care in the context of Staphylococcal infections: a retrospective observational cohort study

Michael Blank; Richard C Wilson; Yu Wan; Joanna Peters; Frances Davies; Lidia Tyszczuk; Bruno Pichon; Alaa Riezk; Alicia Demirjian; Colin Stewart Brown; Mark Gilchrist; Alison H Holmes; Timothy Miles Rawson

doi:10.1016/j.jinf.2024.106191

Exploring real-world vancomycin target attainment in neonatal intensive care in the context of Staphylococcal infections: a retrospective observational cohort study

J Infect. 2024 Aug;89(2):106191. doi: 10.1016/j.jinf.2024.106191. Epub 2024 Jun 5.

Authors

Affiliations

¹ Imperial College Healthcare NHS Trust, Hammersmith Hospital, Du Cane Road, London W12 0HS. United Kingdom. Electronic address: michael.blank@nhs.net.
² Imperial College Healthcare NHS Trust, Hammersmith Hospital, Du Cane Road, London W12 0HS. United Kingdom; National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Department for Infectious Disease, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN. United Kingdom; Centre for Antimicrobial Optimisation, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom; David Price Evans Infectious Diseases & Global Health Group, The University of Liverpool, Liverpool L7 8TX, United Kingdom.
³ Imperial College Healthcare NHS Trust, Hammersmith Hospital, Du Cane Road, London W12 0HS. United Kingdom; National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Department for Infectious Disease, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN. United Kingdom; Healthcare-Associated Infection (HCAI), Fungal, Antimicrobial Resistance (AMR), Antimicrobial Use (AMU) & Sepsis Division, UK Health Security Agency (UKHSA), 61 Colindale Avenue London NW9 5EQ, United Kingdom.
⁴ Imperial College Healthcare NHS Trust, Hammersmith Hospital, Du Cane Road, London W12 0HS. United Kingdom.
⁵ Imperial College Healthcare NHS Trust, Hammersmith Hospital, Du Cane Road, London W12 0HS. United Kingdom; National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Department for Infectious Disease, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN. United Kingdom.
⁶ Healthcare-Associated Infection (HCAI), Fungal, Antimicrobial Resistance (AMR), Antimicrobial Use (AMU) & Sepsis Division, UK Health Security Agency (UKHSA), 61 Colindale Avenue London NW9 5EQ, United Kingdom.
⁷ National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Department for Infectious Disease, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN. United Kingdom; Centre for Antimicrobial Optimisation, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom.
⁸ National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Department for Infectious Disease, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN. United Kingdom; Healthcare-Associated Infection (HCAI), Fungal, Antimicrobial Resistance (AMR), Antimicrobial Use (AMU) & Sepsis Division, UK Health Security Agency (UKHSA), 61 Colindale Avenue London NW9 5EQ, United Kingdom; Department of Paediatric Infectious Disease & Immunology, Evelina London Children's Hospital, London, UK; Faculty of Life Sciences & Medicine, Kings College London, London, UK; Faculty of Medicine, Imperial College London, London, UK.
⁹ Imperial College Healthcare NHS Trust, Hammersmith Hospital, Du Cane Road, London W12 0HS. United Kingdom; National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Department for Infectious Disease, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN. United Kingdom; Centre for Antimicrobial Optimisation, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom.
¹⁰ National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Department for Infectious Disease, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN. United Kingdom; Centre for Antimicrobial Optimisation, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom; David Price Evans Infectious Diseases & Global Health Group, The University of Liverpool, Liverpool L7 8TX, United Kingdom.

PMID: 38848967
DOI: 10.1016/j.jinf.2024.106191

No abstract available

Publication types

Observational Study

MeSH terms

Anti-Bacterial Agents* / therapeutic use
Female
Humans
Infant, Newborn
Intensive Care Units, Neonatal
Intensive Care, Neonatal
Male
Microbial Sensitivity Tests
Retrospective Studies
Staphylococcal Infections* / drug therapy
Staphylococcal Infections* / microbiology
Staphylococcus aureus / drug effects
Vancomycin* / therapeutic use

Substances

Anti-Bacterial Agents
Vancomycin