Examining time-varying dynamics of co-occurring depressed mood and anxiety

J Affect Disord. 2024 Oct 1:362:24-35. doi: 10.1016/j.jad.2024.06.064. Epub 2024 Jun 19.

Abstract

Background: Dimensional frameworks of psychopathology call for multivariate approaches to map co-occurring disorders to index what symptoms emerge when and for whom. Ecological momentary assessment (EMA) offers a method for assessing and differentiating the dynamics of co-occurring symptoms with greater temporal granularity and naturalistic context. The present study used multivariate mixed effects location-scale modeling to characterize the time-varying dynamics of depressed mood and anxiety for women diagnosed with social anxiety disorder (SAD) and major depression (MDD).

Methods: Women completed five daily EMA surveys over 30 days (150 EMA surveys/woman, T ≈ 5250 total observations) and two clinical diagnostic and retrospective self-report measures administered approximately two months apart.

Results: There was evidence of same-symptom lagged effects (bs = 0.08-0.09), but not cross-symptom lagged effects (bs < 0.01) during EMA. Symptoms co-varied such that momentary spikes from one's typical level of anxiety were associated with increases in momentary depressed mood (b = 0.19) and greater variability of depressed mood (b = 0.06). Similarly, spikes from one's typical levels of depressed mood were associated with increases in momentary anxiety (b = 0.19). Furthermore, the presence and magnitude of effects demonstrated person-specific heterogeneity.

Limitations: Our findings are constrained to the dynamics of depressed and anxious mood among cisgender women with primary SAD and current or past MDD.

Conclusions: Findings from this work help to characterize how daily experiences of co-occurring mood and anxiety fluctuate and offer insight to aid the development of momentary, person-specific interventions designed to regulate symptom fluctuations.

Keywords: Affective dynamics; Ecological momentary assessment; Heterogeneity; HiTOP; Internalizing.

MeSH terms

  • Adult
  • Anxiety / epidemiology
  • Anxiety / psychology
  • Depression / epidemiology
  • Depression / psychology
  • Depressive Disorder, Major* / epidemiology
  • Depressive Disorder, Major* / psychology
  • Ecological Momentary Assessment*
  • Female
  • Humans
  • Middle Aged
  • Phobia, Social / epidemiology
  • Phobia, Social / psychology
  • Retrospective Studies
  • Self Report
  • Young Adult