Functional HRD by RAD51 identifies BRCA1 VUS associated with loss of gene function and response to DNA-damaging agents

ESMO Open. 2024 Jul;9(7):103629. doi: 10.1016/j.esmoop.2024.103629. Epub 2024 Jul 5.
No abstract available

Publication types

  • Letter

MeSH terms

  • BRCA1 Protein* / genetics
  • BRCA1 Protein* / metabolism
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / genetics
  • DNA Damage*
  • Female
  • Humans
  • Loss of Function Mutation
  • Rad51 Recombinase* / metabolism

Substances

  • BRCA1 Protein
  • Rad51 Recombinase
  • BRCA1 protein, human
  • RAD51 protein, human