Missed Opportunities for HIV Confirmatory Testing Using an Institutional Testing Algorithm Without Reflex to HIV Nucleic Acid Testing

Lauryn Caster; Olivia R Paetz; Harlan Sayles; Paul D Fey; Sara H Bares

doi:10.1097/OLQ.0000000000001985

Missed Opportunities for HIV Confirmatory Testing Using an Institutional Testing Algorithm Without Reflex to HIV Nucleic Acid Testing

Sex Transm Dis. 2024 Aug 1;51(8):545-547. doi: 10.1097/OLQ.0000000000001985. Epub 2024 Apr 27.

Authors

Lauryn Caster¹, Olivia R Paetz¹, Harlan Sayles², Paul D Fey³, Sara H Bares⁴

Affiliations

¹ From the Colleges of Medicine.
² Public Health.
³ Departments of Pathology and Microbiology.
⁴ Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, NE.

PMID: 38989902
DOI: 10.1097/OLQ.0000000000001985

Abstract

At our medical center, HIV nucleic acid tests are recommended when the HIV antigen-antibody screening immunoassay and antibody differentiation tests are discordant, but not done reflexively. A retrospective chart review found that 35% of discordant test results did not have HIV nucleic acid test completed as recommended.

MeSH terms

Adult
Algorithms*
Female
HIV Antibodies / blood
HIV Infections* / diagnosis
HIV Testing
HIV-1 / immunology
HIV-1 / isolation & purification
Humans
Immunoassay / methods
Male
Mass Screening / methods
Middle Aged
Nucleic Acid Amplification Techniques*
RNA, Viral
Retrospective Studies

Substances

RNA, Viral
HIV Antibodies