[Appendix ... it's not just appendicitis: neuroendocrine tumors]

Recenti Prog Med. 2024 Jul-Aug;115(7):361-365. doi: 10.1701/4314.42991.
[Article in Italian]

Abstract

Well-differentiated neuroendocrine tumors of the appendix (NETs) are rare in pediatric and adolescent age groups. However, they are the most common gastrointestinal epithelial tumor in this age group and the most common malignancy of the appendix in the general population. The classification of these tumors considers factors such as the proliferation index, size of the neoplasm, and the presence of perineural and/or lymphovascular invasion, which can contribute to distant metastases. Preoperative diagnosis is challenging, except in cases where patients exhibit symptoms of carcinoid syndrome or signs of metastatic disease, which are uncommon in pediatric and adolescent patients. For tumors smaller than 1 cm, appendectomy is usually curative, while larger tumors or those at risk of spreading may require right hemicolectomy with lymphadenectomy. We present a case of an adolescent with NET and provide a literature review on the diagnostic and therapeutic approaches that should be considered for this relatively rare condition.Key words. Adolescent age, appendix, neuroendocrine tumors, pediatric age.

Publication types

  • Case Reports
  • Review
  • English Abstract

MeSH terms

  • Adolescent
  • Appendectomy* / methods
  • Appendiceal Neoplasms* / diagnosis
  • Appendiceal Neoplasms* / pathology
  • Appendiceal Neoplasms* / surgery
  • Appendicitis* / diagnosis
  • Appendicitis* / pathology
  • Appendicitis* / surgery
  • Colectomy / methods
  • Humans
  • Neuroendocrine Tumors* / diagnosis
  • Neuroendocrine Tumors* / pathology
  • Neuroendocrine Tumors* / surgery