Visible-Light-Induced Synthesis of Vinyl Sulfones via Decarboxylative Sulfonylation of Cinnamic Acids Using Sulfonylazides/ p-Toluenesulfonylmethyl Isocyanide/β-Keto Sulfones

J Org Chem. 2024 Aug 2;89(15):10919-10928. doi: 10.1021/acs.joc.4c01252. Epub 2024 Jul 16.

Abstract

An efficient visible-light-induced synthesis of vinyl sulfones has been accomplished via decarboxylative sulfonylation of cinnamic acids using sulfonylazides, p-toluenesulfonylmethyl isocyanide, and β-keto sulfones as sulfonyl source, in the presence of inexpensive organic photocatalysts like rhodamine B and eosin Y. The reaction is facile, straightforward, and endowed with wide substrate scope and functional group tolerability.