The virome of bubaline (Bubalus bubalis) tonsils reveals an unreported bubaline polyomavirus

Braz J Microbiol. 2024 Sep;55(3):2893-2900. doi: 10.1007/s42770-024-01449-0. Epub 2024 Jul 16.

Abstract

Water buffalo (Bubalus bubalis) farming is increasing in many regions of the world due to the species' ability to thrive in environments where bovine cattle would struggle. Despite water buffaloes being known for their resistance to diseases, there is a lack of data about the diversity of the microbiome of the species. In this study, we examined the virome diversity in palatine tonsils collected from animals from the island of Marajó, northern Pará state, Brazil, which harbors the largest bubaline flock in the country. Tonsil fragments from 60 clinically healthy bubalines were randomly selected from a sample of 293 animals. The samples were purified, extracted, and randomly amplified with phi29 DNA polymerase. After amplification, the products were purified and sequenced. Circular DNA viruses were predominant in the tonsils' virome. Sequences of genome segments representative of members of the genera Alphapolyomavirus (including a previously unreported bubaline polyomavirus genome) and Gemycircularvirus were identified, along with other not yet classified circular virus genomes. As the animals were clinically healthy at the time of sampling, such viruses likely constitute part of the normal tonsillar virome of water buffaloes inhabiting the Ilha do Marajó biome.

Keywords: Circular DNA viruses; Marajó Island, Brazil; Tonsils; Virome; Water buffalo.

MeSH terms

  • Animals
  • Brazil
  • Buffaloes* / virology
  • DNA, Viral / genetics
  • Genome, Viral
  • Palatine Tonsil* / virology
  • Phylogeny*
  • Polyomavirus* / classification
  • Polyomavirus* / genetics
  • Polyomavirus* / isolation & purification
  • Virome

Substances

  • DNA, Viral