The Incidence and Outcomes of Venous Thromboembolisms in Patients Admitted with Different Gastrointestinal Malignancies

Mohammad Darweesh; Metri Haddaden; Zainab Fatima; Mahmoud Mansour; Rami Dalbah; Suhib Fahmawi; Ratib Mahfouz; Adham E Obeidat; Bhavesh Gajjar

doi:10.1159/000538057

The Incidence and Outcomes of Venous Thromboembolisms in Patients Admitted with Different Gastrointestinal Malignancies

Gastrointest Tumors. 2024 Jun 11;10(1):67-73. doi: 10.1159/000538057. eCollection 2023 Jan-Dec.

Authors

Mohammad Darweesh¹, Metri Haddaden², Zainab Fatima¹, Mahmoud Mansour³, Rami Dalbah¹, Suhib Fahmawi¹, Ratib Mahfouz⁴, Adham E Obeidat⁵, Bhavesh Gajjar¹

Affiliations

¹ Department of Internal Medicine, East Tennessee State University, Johnson City, TN, USA.
² Department of Internal Medicine, Griffin Hospital, Yale University School of Medicine, Derby, CT, USA.
³ Department of Internal Medicine, University of Missouri, Columbia, MO, USA.
⁴ Department of Internal Medicine, Kent Hospital, Brown University, Warwick, RI, USA.
⁵ Department of Internal Medicine, University of Hawaii, Honolulu, HI, USA.

Abstract

Introduction: Venous thromboembolism (VTE) is associated with significant morbidity and mortality in cancer patients. Our study compares the mortality in hospitalized VTE patients among the four most common gastrointestinal (GI) malignancies which include esophageal, gastric, pancreatic, and colorectal cancer.

Methods: A retrospective study was conducted utilizing the Nationwide Inpatient Sample database (NIS) from 2016 to 2019. Patients with VTE were identified using ICD-10 codes from all primary discharge diagnoses. Only deep venous thrombosis (DVT) and pulmonary embolism (PE) were considered. Patients with VTE were further divided into groups: esophageal cancer, gastric cancer, pancreatic cancer, and colorectal cancer, and compared with patients who did not have these malignancies. The adjusted odds ratio (aOR) was calculated using multivariate regression analysis.

Results: Among 999,559 patients discharged with a VTE diagnosis, 25,775 (2.6%) had one of the four GI malignancies. Among patients with one of the four included GI malignancy diagnosis, 18,816 (73%) patients had PE and 6,959 (27%) patients had DVT. The study shows that adults admitted to the hospitals for VTE have higher mortality when compared to patients who did not have GI malignancies, with esophageal cancer having the highest inpatient mortality with an aOR of 2.701; 95% confidence interval (CI) 1.989-3.669, p value <0.000. For the remaining GI cancers, gastric cancer had an aOR 1.576; CI: 1.094-2.269, p value 0.015, and pancreatic cancer had an aOR of 1.736; 95% CI: 1.445-2.085, p value <0.000. Patients with colorectal cancer had no significant increase in the odds of mortality with aOR of 1.213; 95% CI: 0.988-1.489, p value 0.066.

Conclusions: This study demonstrates that VTE in hospitalized patients with esophageal cancer is associated with greater mortality compared to other GI malignancies.

Keywords: Deep vein thrombosis; Esophageal cancer; Gastrointestinal malignancies; Pulmonary embolism; Venous thromboembolism.

Grants and funding

No funding has been received in the preparation of data or the manuscript.