Ion release of the glass ionomer restoration with silver diamine fluoride dentin pretreatment

Kelsey Xingyun Ge; Ryan Quock; Feng Yan; Walter Yu-Hang Lam; Chun-Hung Chu; Ollie Yiru Yu

doi:10.1016/j.jdent.2024.105247

Ion release of the glass ionomer restoration with silver diamine fluoride dentin pretreatment

J Dent. 2024 Sep:148:105247. doi: 10.1016/j.jdent.2024.105247. Epub 2024 Jul 23.

Authors

Kelsey Xingyun Ge¹, Ryan Quock², Feng Yan³, Walter Yu-Hang Lam¹, Chun-Hung Chu¹, Ollie Yiru Yu⁴

Affiliations

¹ Faculty of Dentistry, The University of Hong Kong, Hong Kong, S.A.R., PR China.
² Faculty of Dentistry, The University of Hong Kong, Hong Kong, S.A.R., PR China; Department of Restorative Dentistry and Prosthodontics, School of Dentistry, The University of Texas Health Science Center at Houston, Texas, USA.
³ Department of Applied Physics, The Hong Kong Polytechnic University, Research Institute for Intelligent Wearable Systems, Hong Kong, S.A.R., PR China.
⁴ Faculty of Dentistry, The University of Hong Kong, Hong Kong, S.A.R., PR China. Electronic address: ollieyu@hku.hk.

PMID: 39025427
DOI: 10.1016/j.jdent.2024.105247

Abstract

Objective: To assess the fluoride and silver ion release of glass ionomer cement (GIC) restorations, including conventional GIC (CGIC) and resin-modified GIC (RMGIC) restorations, with 38 % silver diamine fluoride (SDF) solution dentin pretreatment.

Methods: Eighty dentin blocks were allocated into 4 groups and restored with SDF+CGIC, CGIC, SDF+RMGIC and RMGIC, respectively. Each block was stored in deionized water at 37 °C for 2 years. Fluoride and silver ion concentration in storage solution was measured using ion-selective electrode and inductively coupled plasma-optical emission spectrometry for up to 2 years. The cross-sectional surfaces of restored dentin blocks were assessed by X-Ray diffraction analysis (XRD), scanning electron microscope (SEM) with energy-dispersive X-ray spectroscopy (EDS) after 1 week and 2 years, respectively.

Results: The mean ± standard deviation (SD) of accumulative fluoride releasing in SDF+CGIC, CGIC, SDF+RMGIC and RMGIC for 2 years were 0.13±0.005 mg, 0.09±0.006 mg, 0.15±0.008 mg and 0.05±0.003 mg, respectively (Groups SDF+RMGIC > SDF+CGIC > CGIC >RMGIC, p < 0.05). The mean ± SD of accumulative silver releasing in SDF+CGIC, CGIC, SDF+RMGIC and RMGIC for 2 years were 0.03±0.009 mg, 0.00±0.00 mg, 0.01±0.003 mg, and 0.00±0.00 mg, respectively (Groups SDF+CGIC > SDF+RMGIC > CGIC&RMGIC, p < 0.05). Groups SDF+CGIC and SDF+RMGIC showed sustainably higher fluoride and silver releasing compared to Groups CGIC and RMGIC (p < 0.05). XRD analysis indicated the fluorapatite and silver chloride were observed only in Groups SDF+CGIC and SDF+RMGIC, but not in Groups CGIC and RMGIC. SEM images of the cross-sectional view of the dentin blocks showed silver crystals within dentinal tubules 1 week and 2-year in Groups with SDF pretreatment.

Conclusion: The 38 % SDF dentin pretreatment sustainably increased the fluoride and silver release of GIC and RMGIC restorations for up to 2 years.

Keywords: Fluoride; Glass ionomer cement; Ion release; Silver; Silver diamine fluoride.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cariostatic Agents / chemistry
Dental Restoration, Permanent / methods
Dentin* / chemistry
Dentin* / drug effects
Fluorides* / chemistry
Fluorides, Topical* / chemistry
Glass Ionomer Cements* / chemistry
Humans
Ion-Selective Electrodes
Materials Testing
Microscopy, Electron, Scanning*
Quaternary Ammonium Compounds* / chemistry
Resin Cements / chemistry
Silver Compounds* / chemistry
Silver* / chemistry
Spectrometry, X-Ray Emission*
Surface Properties
X-Ray Diffraction*

Substances

Silver Compounds
silver diamine fluoride
Quaternary Ammonium Compounds
Glass Ionomer Cements
Fluorides
Fluorides, Topical
Silver
Cariostatic Agents
Resin Cements