Identification of a putative molecular subtype of adult-type diffuse astrocytoma with recurrent MAPK pathway alterations

Philipp Sievers; Franck Bielle; Kirsten Göbel; Daniel Schrimpf; Lucia Nichelli; Bertrand Mathon; Romain Appay; Henning B Boldt; Hildegard Dohmen; Carmen Selignow; Till Acker; Ales Vicha; Horacio Martinetto; Leonille Schweizer; Ulrich Schüller; Sebastian Brandner; Pieter Wesseling; Simone Schmid; David Capper; Zied Abdullaev; Kenneth Aldape; Andrey Korshunov; Sandro M Krieg; Wolfgang Wick; Stefan M Pfister; Andreas von Deimling; David E Reuss; David T W Jones; Felix Sahm

doi:10.1007/s00401-024-02766-2

Identification of a putative molecular subtype of adult-type diffuse astrocytoma with recurrent MAPK pathway alterations

Acta Neuropathol. 2024 Jul 18;148(1):7. doi: 10.1007/s00401-024-02766-2.

Authors

Philipp Sievers^#^{1

2

3}, Franck Bielle^#^{4

5}, Kirsten Göbel^{6

7}, Daniel Schrimpf^{6

7}, Lucia Nichelli^{4

8}, Bertrand Mathon^{4

9}, Romain Appay^{10

11}, Henning B Boldt^{12

13}, Hildegard Dohmen¹⁴, Carmen Selignow¹⁴, Till Acker¹⁴, Ales Vicha^{15

16}, Horacio Martinetto¹⁷, Leonille Schweizer^{18

19

20}, Ulrich Schüller^{21

22

23}, Sebastian Brandner^{24

25}, Pieter Wesseling^{26

27}, Simone Schmid²⁸, David Capper^{28

29

30}, Zied Abdullaev³¹, Kenneth Aldape³¹, Andrey Korshunov^{6

7

32}, Sandro M Krieg³³, Wolfgang Wick^{34

35}, Stefan M Pfister^{32

36

37

38}, Andreas von Deimling^{6

7}, David E Reuss^{6

7}, David T W Jones^#^{32

38

39}, Felix Sahm^#^{6

7

32

38}

Affiliations

¹ Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany. philipp.sievers@med.uni-heidelberg.de.
² Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. philipp.sievers@med.uni-heidelberg.de.
³ Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. philipp.sievers@med.uni-heidelberg.de.
⁴ Sorbonne Université, Inserm, CNRS, UMR S 1127, Paris Brain Institute, ICM, 75013, Paris, France.
⁵ Department of Neuropathology, AP-HP, Pitié-Salpêtrière Hospital, 75013, Paris, France.
⁶ Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
⁷ Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁸ Department of Neuroradiology, AP-HP, Pitié-Salpêtrière Hospital, 75013, Paris, France.
⁹ Department of Neurosurgery, AP-HP, Pitié-Salpêtrière Hospital, 75013, Paris, France.
¹⁰ Department of Pathology and Neuropathology, APHM, CHU Timone, Marseille, France.
¹¹ Institute of Neurophysiopathol, CNRS, INP, Aix-Marseille University, Marseille, France.
¹² Department of Pathology, Odense University Hospital, Odense, Denmark.
¹³ Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
¹⁴ Institute of Neuropathology, Justus-Liebig University Giessen, Giessen, Germany.
¹⁵ Prague Brain Tumor Research Group, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
¹⁶ Department of Pediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
¹⁷ Departamento de Neuropatología y Biología Molecular, Instituto de Investigaciones Neurológicas Dr Raúl Carrea (FLENI), Buenos Aires, Argentina.
¹⁸ Institute of Neurology (Edinger Institute), University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
¹⁹ German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, German Cancer Research Center (DKFZ), Heidelberg, Germany.
²⁰ Frankfurt Cancer Institute (FCI), Frankfurt am Main, Germany.
²¹ Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
²² Research Institute Children's Cancer Center Hamburg, Hamburg, Germany.
²³ Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
²⁴ Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London, UK.
²⁵ Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London, UK.
²⁶ Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
²⁷ Department of Pathology, Amsterdam University Medical Centers, Location VUmc and Brain Tumor Center Amsterdam, Amsterdam, The Netherlands.
²⁸ Department of Neuropathology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
²⁹ Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Berlin, Germany.
³⁰ German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany.
³¹ Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
³² Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
³³ Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.
³⁴ Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
³⁵ Department of Neurology and Neurooncology Program, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.
³⁶ Division of Pediatric Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
³⁷ Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany.
³⁸ National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.
³⁹ Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.

^# Contributed equally.

No abstract available

Publication types

Letter

MeSH terms

Adult
Astrocytoma* / genetics
Astrocytoma* / pathology
Brain Neoplasms* / genetics
Brain Neoplasms* / pathology
Female
Humans
MAP Kinase Signaling System* / genetics
MAP Kinase Signaling System* / physiology
Male
Middle Aged
Mutation / genetics

Grants and funding

2021_EKMS.15/Else Kröner-Fresenius-Stiftung