Temozolomide use in elderly patients with MGMT promoter unmethylated glioblastoma: Is it finally time to dismount a dead horse?

Neuro Oncol. 2024 Oct 3;26(10):1876-1877. doi: 10.1093/neuonc/noae143.
No abstract available

Publication types

  • Comment

MeSH terms

  • Aged
  • Antineoplastic Agents, Alkylating* / therapeutic use
  • Brain Neoplasms* / drug therapy
  • Brain Neoplasms* / genetics
  • DNA Methylation*
  • DNA Modification Methylases* / genetics
  • DNA Repair Enzymes* / genetics
  • Dacarbazine / analogs & derivatives
  • Dacarbazine / therapeutic use
  • Glioblastoma* / drug therapy
  • Glioblastoma* / genetics
  • Humans
  • Promoter Regions, Genetic*
  • Temozolomide* / therapeutic use
  • Tumor Suppressor Proteins* / genetics

Substances

  • Antineoplastic Agents, Alkylating
  • Dacarbazine
  • DNA Modification Methylases
  • DNA Repair Enzymes
  • MGMT protein, human
  • Temozolomide
  • Tumor Suppressor Proteins