Single-nucleus RNA sequencing identifies cell-type-specific effects of sodium-glucose co-transporter 2 inhibitors in human myocardial slices

Kevin Schmidt; Maximilian Fuchs; Natalie Weber; Christopher Werlein; Jan D Schmitto; Fabio Ius; Arjang Ruhparwar; Christian Bär; Jan Fiedler; Thomas Thum

doi:10.1093/eurheartj/ehae472

Single-nucleus RNA sequencing identifies cell-type-specific effects of sodium-glucose co-transporter 2 inhibitors in human myocardial slices

Eur Heart J. 2024 Sep 14;45(35):3292-3295. doi: 10.1093/eurheartj/ehae472.

Authors

Kevin Schmidt^{1

2

3}, Maximilian Fuchs^{2

3}, Natalie Weber^{1

4}, Christopher Werlein⁵, Jan D Schmitto^{4

6}, Fabio Ius^{4

6}, Arjang Ruhparwar^{4

6}, Christian Bär^{1

2

3

4}, Jan Fiedler^{1

2

3}, Thomas Thum^{1

4}

Affiliations

¹ Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
² Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, Germany.
³ Fraunhofer Cluster of Excellence Immune-Mediated Diseases (CIMD), Hannover, Germany.
⁴ Center for Translational Regenerative Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
⁵ Institute of Pathology, Hannover Medical School, Hannover, Germany.
⁶ Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.

No abstract available

Keywords: Cardiovascular diseases; Heart failure; Human living myocardial slices; Single-nucleus RNA sequencing; Sodium-glucose co-transporter 2 inhibitors.

MeSH terms

Benzhydryl Compounds / pharmacology
Benzhydryl Compounds / therapeutic use
Glucosides
Humans
Myocardium* / metabolism
Myocardium* / pathology
Sequence Analysis, RNA
Sodium-Glucose Transporter 2 Inhibitors* / pharmacology
Sodium-Glucose Transporter 2 Inhibitors* / therapeutic use

Substances

Sodium-Glucose Transporter 2 Inhibitors
Benzhydryl Compounds
empagliflozin
Glucosides

Grants and funding

437531118/Deutsche Forschungsgemeinschaft