Stem Cell Therapy for Wound Healing in Ischemic Limbs: Is It Effective?

Li Ting Tan; Farzad Mokhtari-Esbuie; Niloufar Shababi; John W Harmon

doi:10.1016/j.yasu.2024.04.014

Stem Cell Therapy for Wound Healing in Ischemic Limbs: Is It Effective?

Adv Surg. 2024 Sep;58(1):235-247. doi: 10.1016/j.yasu.2024.04.014. Epub 2024 Jun 6.

Authors

Li Ting Tan¹, Farzad Mokhtari-Esbuie², Niloufar Shababi², John W Harmon³

Affiliations

¹ Department of Surgery, The Johns Hopkins Hospital, Blalock 658, 600 North Wolfe Street, Baltimore, MD 21287, USA.
² Department of Surgery, Johns Hopkins University, Surgery A Building 5th Floor, 4940 Eastern Avenue, Baltimore, MD 21224, USA.
³ Department of Surgery, Johns Hopkins University, Surgery A Building 5th Floor, 4940 Eastern Avenue, Baltimore, MD 21224, USA. Electronic address: jharmon@jhmi.edu.

PMID: 39089780
DOI: 10.1016/j.yasu.2024.04.014

Abstract

Critical limb ischemia is an important clinical entity due to its association with increased morbidity and mortality. The mortality and amputation-free survival remains poor especially in those where revascularization is not an option. Recently, the role of cellular therapy has emerged as a promising therapeutic measure that may aid in wound healing and revascularization and improve functional outcomes.

Keywords: Bone marrow-derived cells; Critical limb ischemia; Mesenchymal stem cells; Mononuclear stem cells; Stem cell therapy.

Publication types

Review

MeSH terms

Humans
Ischemia* / therapy
Stem Cell Transplantation / methods
Treatment Outcome
Wound Healing* / physiology