Cell-free DNA analysis for recurrent respiratory papillomatosis: A case report

Satoshi Yamada; Kotaro Kano; Ryuji Ishikawa; Atsushi Imai; Daiki Mochizuki; Kotaro Morita; Kazutaka Takeuchi; Yoshinori Takizawa; Hideya Kawasaki; Kiyoshi Misawa

doi:10.1002/ccr3.9268

Cell-free DNA analysis for recurrent respiratory papillomatosis: A case report

Clin Case Rep. 2024 Aug 6;12(8):e9268. doi: 10.1002/ccr3.9268. eCollection 2024 Aug.

Authors

Affiliations

¹ Department of Otolaryngology/Head and Neck Surgery Hamamatsu University School of Medicine Hamamatsu Japan.
² Department of Otolaryngology Yaizu City Hospital Yaizu Japan.
³ Institute for NanoSuit Research, Preeminent Medical Photonics Education and Research Center Hamamatsu University School of Medicine Hamamatsu Japan.

Abstract

A 35-year-old male presented with recurrent respiratory papillomatosis. Human papillomavirus type 11 was detected from all sites of tumor tissue DNA by PCR. The pre-surgery cell-free DNA (cfDNA) viral load (3.33 × 10³ copies/ng DNA) fell below the post-surgical detection limits on achieving remission, suggesting cfDNA's potential as a biomarker.

Keywords: cfDNA; human papillomavirus; recurrent respiratory papillomatosis; viral load.

Publication types

Case Reports