TRPC1: The housekeeper of the hippocampus

Julia Skerjanz; Lena Bauernhofer; Kerstin Lenk; Anita Emmerstorfer-Augustin; Gerd Leitinger; Florian Reichmann; Thomas Stockner; Klaus Groschner; Oleksandra Tiapko

doi:10.1016/j.ceca.2024.102933

TRPC1: The housekeeper of the hippocampus

Cell Calcium. 2024 Nov:123:102933. doi: 10.1016/j.ceca.2024.102933. Epub 2024 Jul 27.

Authors

Julia Skerjanz¹, Lena Bauernhofer², Kerstin Lenk³, Anita Emmerstorfer-Augustin⁴, Gerd Leitinger⁵, Florian Reichmann⁶, Thomas Stockner⁷, Klaus Groschner¹, Oleksandra Tiapko⁸

Affiliations

¹ Gottfried Schatz Research Center, Division of Medical Physics and Biophysics, Medical University of Graz, Austria.
² Biophysics Division, Institute of Molecular Biosciences, NAWI Graz, University of Graz, Austria; BioTechMed-Graz, Austria.
³ Institute of Neural Engineering, Graz University of Technology, Austria; BioTechMed-Graz, Austria.
⁴ Institute of Molecular Biotechnology, Graz University of Technology, Austria; BioTechMed-Graz, Austria.
⁵ Gottfried Schatz Research Center, Division of Cell Biology, Histology and Embryology, Medical University of Graz, Austria; BioTechMed-Graz, Austria; MEFOgraz, Austria.
⁶ Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Austria; BioTechMed-Graz, Austria.
⁷ Department of Pharmacology, Medical University of Vienna, Vienna, Austria.
⁸ Gottfried Schatz Research Center, Division of Medical Physics and Biophysics, Medical University of Graz, Austria; BioTechMed-Graz, Austria; MEFOgraz, Austria. Electronic address: oleksandra.tiapko@medunigraz.at.

PMID: 39116710
DOI: 10.1016/j.ceca.2024.102933

Abstract

The non-selective cation channel TRPC1 is highly expressed in the brain. Recent research shows that neuronal TRPC1 forms heteromeric complexes with TRPC4 and TRPC5, with a small portion existing as homotetramers, primarily in the ER. Given that most studies have focused on the role of heteromeric TRPC1/4/5 complexes, it is crucial to investigate the specific role of homomeric TRPC1 in maintaining brain homeostasis. This review highlights recent findings on TRPC1 in the brain, with a focus on the hippocampus, and compiles the latest data on modulators and their binding sites within the TRPC1/4/5 subfamily to stimulate new research on more selective TRPC1 ligands.

Keywords: ER homeostasis; Hippocampus; TRPC ligands; TRPC1.

Publication types

Review

MeSH terms

Animals
Hippocampus* / metabolism
Humans
TRPC Cation Channels* / metabolism

Substances

TRPC Cation Channels
transient receptor potential cation channel, subfamily C, member 1