Alpha synuclein PET imaging, a step closer to in vivo neuropathology in Parkinson's disease and related disorders

Neuron. 2024 Aug 7;112(15):2457-2458. doi: 10.1016/j.neuron.2024.07.001.

Abstract

In this issue of Neuron, Endo et al.1 develop a PET tracer capable of detecting alpha-synuclein (ɑ-syn). With validation in animal models and humans, this tracer brings us closer to being able to monitor the synuclein aggregation process and associated pathological changes in Parkinson's disease (PD) and other synucleinopathies.

MeSH terms

  • Animals
  • Humans
  • Parkinson Disease* / diagnostic imaging
  • Parkinson Disease* / metabolism
  • Parkinson Disease* / pathology
  • Positron-Emission Tomography* / methods
  • Synucleinopathies / diagnostic imaging
  • Synucleinopathies / metabolism
  • Synucleinopathies / pathology
  • alpha-Synuclein* / metabolism

Substances

  • alpha-Synuclein