Geographic Atrophy-associated Intraretinal Neovascularization (GAIN): A novel clinical entity

Riccardo Sacconi; Federico Beretta; Francesco Bandello; Giuseppe Querques

doi:10.1007/s00417-024-06610-x

Geographic Atrophy-associated Intraretinal Neovascularization (GAIN): A novel clinical entity

Graefes Arch Clin Exp Ophthalmol. 2024 Aug 15. doi: 10.1007/s00417-024-06610-x. Online ahead of print.

Authors

Riccardo Sacconi^{1

2}, Federico Beretta^{1

2}, Francesco Bandello^{1

2}, Giuseppe Querques^{3

4}

Affiliations

¹ School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
² Division of Head and Neck, Ophthalmology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
³ School of Medicine, Vita-Salute San Raffaele University, Milan, Italy. giuseppe.querques@hotmail.it.
⁴ Division of Head and Neck, Ophthalmology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy. giuseppe.querques@hotmail.it.

PMID: 39145794
DOI: 10.1007/s00417-024-06610-x

Abstract

KEY MESSAGES : WHAT IS KNOWN : Geographic atrophy could be associated with MNV or other vascular alterations. Intraretinal fluid could be present in GA also without neovascularization. WHAT IS NEW : GAIN is a novel clinical entity characterized by GA and an intraretinal neovascular network. GAIN could be exudative or non-exudative.

Keywords: Age-related macular degeneration; Biomarker; Geographic atrophy; MNV; Macular neovascularization; Neovascularization; Reticular pseudodrusen; Subretinal drusenoid deposits.