Abstract
91 healthy contacts of leprosy patients were studied for subclinical infection and possibly the pre-clinical stage of the disease using a battery of tests. It was observed that the test based on competitive inhibition of monoclonal antibody binding to the MY2 a determinant of M. leprae identifies a preclinical stage of the disease.
MeSH terms
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Adolescent
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Adult
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Antibodies, Bacterial / analysis*
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Antibodies, Monoclonal / analysis
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Antibodies, Monoclonal / immunology
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Antigen-Antibody Complex / analysis
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Biopsy
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Child
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Child, Preschool
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Female
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Fluorescent Antibody Technique
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Humans
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Infant
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Lepromin
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Leprosy / diagnosis
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Leprosy / immunology
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Leprosy / pathology
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Leprosy / transmission*
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Male
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Mycobacterium leprae / immunology*
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Nasal Mucosa / pathology
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Sepsis
Substances
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Antibodies, Bacterial
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Antibodies, Monoclonal
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Antigen-Antibody Complex
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Lepromin