Uncovering patterns of inhaler technique and reliever use: the value of objective, personalized data from a digital inhaler

NPJ Prim Care Respir Med. 2024 Aug 20;34(1):23. doi: 10.1038/s41533-024-00382-x.

Abstract

Electronic inhalers provide information about patterns of routine inhaler use. During a 12-week study, 360 asthma patients using albuterol Digihaler generated 53,083 inhaler events that were retrospectively analyzed. A total of 41,528 (78%) of the recorded inhalation events were suitable for flow analysis (having a PIF ≥ 18 L/min and <120 L/min). Median PIF, inhalation volume, inhalation duration, and time to PIF for these events steadily decreased between the first and last 10 days of the study, by 5.1%, 12.6%, 15.9%, and 6.4%, respectively. Continuous short-acting beta2-agonist (SABA) overuse, defined as ≥2 SABA inhalations/week throughout the study period, was seen in 29% (n = 104) of patients. Of 260 patients with ≥1 instance of acute short-term SABA overuse, 55 (21%) had a confirmed exacerbation. Electronic recording of real-life inhaler use can capture valuable, objective information that could inform disease management and clinical decision-making.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Inhalation
  • Adolescent
  • Adrenergic beta-2 Receptor Agonists / administration & dosage
  • Adrenergic beta-2 Receptor Agonists / therapeutic use
  • Adult
  • Aged
  • Albuterol / administration & dosage
  • Albuterol / therapeutic use
  • Asthma* / drug therapy
  • Bronchodilator Agents / administration & dosage
  • Bronchodilator Agents / therapeutic use
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nebulizers and Vaporizers*
  • Retrospective Studies
  • Young Adult

Substances

  • Albuterol
  • Bronchodilator Agents
  • Adrenergic beta-2 Receptor Agonists