Role of allogeneic hematopoietic cell transplantation in VEXAS syndrome

Ann Hematol. 2024 Nov;103(11):4427-4436. doi: 10.1007/s00277-024-05942-2. Epub 2024 Aug 22.

Abstract

VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) is a newly diagnosed syndrome comprising severe systemic inflammatory and hematological manifestations including myelodysplastic syndrome and plasma cell dyscrasia. Since its discovery four years ago, several groups have identified pleomorphic clinical phenotypes, but few effective medical therapies exist which include Janus Kinase (JAK) inhibitors, interleukin inhibitors (IL-1 and IL-6), and hypomethylating agents. Prospective trials are lacking at this time and most patients remain corticosteroid dependent. VEXAS has a high morbidity from frequent life threatening inflammatory symptoms and risk of progression to hematological malignancies and has an overall survival of 50% at 10 years. Allogeneic stem cell transplant (allo-HCT) is a curative option for this disease caused by somatic mutations in the UBA1 gene. Here we outline the role of allo-HCT in treating patients with VEXAS syndrome, highlighting the outcomes from several single-institution studies and case reports. Prospective trials will be required to precisely define the role of allo-HCT in the management of VEXAS syndrome.

Keywords: Allogeneic stem cell transplantation (Allo-HCT); Janus Kinase (JAK) inhibitors; Myelodysplastic syndrome (MDS); VEXAS syndrome.

Publication types

  • Review

MeSH terms

  • Allografts
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Myelodysplastic Syndromes / genetics
  • Myelodysplastic Syndromes / therapy
  • Transplantation, Homologous
  • Ubiquitin-Activating Enzymes / genetics

Substances

  • Ubiquitin-Activating Enzymes
  • UBA1 protein, human