Alterations in the Skin Microbiome in Dermatologic Diseases and with External Exposures: CME Part 2

Margaret A MacGibeny; Susuana Adjei; Hunter Pyle; Christopher G Bunick; Mahmoud Ghannoum; Ayman Grada; Tamia Harris-Tryon; Stephen K Tyring; Heidi H Kong

doi:10.1016/j.jaad.2024.07.1499

Alterations in the Skin Microbiome in Dermatologic Diseases and with External Exposures: CME Part 2

J Am Acad Dermatol. 2024 Aug 20:S0190-9622(24)02672-0. doi: 10.1016/j.jaad.2024.07.1499. Online ahead of print.

Authors

Margaret A MacGibeny¹, Susuana Adjei², Hunter Pyle³, Christopher G Bunick⁴, Mahmoud Ghannoum⁵, Ayman Grada⁶, Tamia Harris-Tryon³, Stephen K Tyring⁷, Heidi H Kong⁸

Affiliations

¹ Department of Dermatology, Yale School of Medicine, New Haven, CT, USA.
² Department of Dermatology, Lake Granbury Medical Center, Dallas, TX, USA.
³ Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
⁴ Department of Dermatology, Yale School of Medicine, New Haven, CT, USA; Program in Translational Biomedicine, Yale School of Medicine, New Haven, CT, USA.
⁵ Integrated Microbiome Core and Center for Medical Mycology, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH, USA; Department of Dermatology, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
⁶ Integrated Microbiome Core and Center for Medical Mycology, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
⁷ Department of Dermatology, Lake Granbury Medical Center, Dallas, TX, USA. Electronic address: styring@ccstexas.com.
⁸ Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address: konghe@mail.nih.gov.

PMID: 39173885
DOI: 10.1016/j.jaad.2024.07.1499

Abstract

In Part I of our CME we reviewed the skin microbiome in healthy individuals. Part II reviews the evolving understanding of alterations in the skin microbiome in specific human diseases. We also discuss how the skin microbiome can change with environmental exposures and medications such as antibiotics as well as ongoing research on microbiome-based interventions.

Keywords: antibiotics; antimicrobial resistance; fecal microbiota transplantation; inflammatory skin diseases; microbiome-based therapeutics; prebiotics; probiotics.

Publication types

Review