Helminth protein enhances wound healing by inhibiting fibrosis and promoting tissue regeneration

Life Sci Alliance. 2024 Aug 23;7(11):e202302249. doi: 10.26508/lsa.202302249. Print 2024 Nov.

Abstract

Skin wound healing due to full thickness wounds typically results in fibrosis and scarring, where parenchyma tissue is replaced with connective tissue. A major advance in wound healing research would be to instead promote tissue regeneration. Helminth parasites express excretory/secretory (ES) molecules, which can modulate mammalian host responses. One recently discovered ES protein, TGF-β mimic (TGM), binds the TGF-β receptor, though likely has other activities. Here, we demonstrate that topical administration of TGM under a Tegaderm bandage enhanced wound healing and tissue regeneration in an in vivo wound biopsy model. Increased restoration of normal tissue structure in the wound beds of TGM-treated mice was observed during mid- to late-stage wound healing. Both accelerated re-epithelialization and hair follicle regeneration were observed. Further analysis showed differential expansion of myeloid populations at different wound healing stages, suggesting recruitment and reprogramming of specific macrophage subsets. This study indicates a role for TGM as a potential therapeutic option for enhanced wound healing.

MeSH terms

  • Animals
  • Disease Models, Animal
  • Fibrosis*
  • Hair Follicle / metabolism
  • Helminth Proteins* / metabolism
  • Helminth Proteins* / pharmacology
  • Macrophages / metabolism
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Re-Epithelialization
  • Regeneration*
  • Skin / injuries
  • Skin / metabolism
  • Transforming Growth Factor beta / metabolism
  • Wound Healing*

Substances

  • Helminth Proteins
  • Transforming Growth Factor beta