G Protein-Coupled Receptors in Skin Aging

Suet Ting Cheung; Yelim Do; Eunah Kim; Antonella Rella; Earl Goyarts; Nadine Pernodet; Yung Hou Wong

doi:10.1016/j.jid.2024.06.1288

G Protein-Coupled Receptors in Skin Aging

J Invest Dermatol. 2024 Aug 25:S0022-202X(24)01919-5. doi: 10.1016/j.jid.2024.06.1288. Online ahead of print.

Authors

Suet Ting Cheung¹, Yelim Do¹, Eunah Kim¹, Antonella Rella², Earl Goyarts², Nadine Pernodet³, Yung Hou Wong⁴

Affiliations

¹ The Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; The Biotechnology Research Institute, The Hong Kong University of Science and Technology, Hong Kong, China.
² Research and Development, The Estée Lauder Companies, New York, New York, USA.
³ Research and Development, The Estée Lauder Companies, New York, New York, USA; Estée Lauder Research Laboratories, Melville, New York, USA.
⁴ The Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; The Biotechnology Research Institute, The Hong Kong University of Science and Technology, Hong Kong, China; Molecular Neuroscience Center, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China; Center for Aging Science, The Hong Kong University of Science and Technology, Hong Kong, China. Electronic address: boyung@ust.hk.

PMID: 39186022
DOI: 10.1016/j.jid.2024.06.1288

Abstract

Skin aging is a complex biological process affected by a plethora of intrinsic and extrinsic factors that alter cutaneous functions through the modulations of signaling pathways and responses. Expressed in various cell types and skin tissue layers, G protein-coupled receptors (GPCRs) play a vital role in regulating skin aging. We have cataloged 156 GPCRs expressed in the skin and reviewed their roles in skin aging, such as pigmentation, loss of elasticity, wrinkles, rough texture, and aging-associated skin disorders. By exploring the GPCRs found in the skin, it may be possible to develop new treatment regimens for aging-associated skin conditions using GPCR ligands.

Keywords: G protein–coupled receptors; Inflammatory skin disease; Photoaging; Skin aging.

Publication types

Review