Suaedamas A-D: Four New Compounds from the Aerial Parts of Suaeda maritima with Inhibition of NO Production Activity

Bui Thi Nha Trang; Bui Thi Mai Anh; Nguyen Thi Mai; Nguyen Thi Cuc; Le Thi Huyen; Nhu Thi Hang Nga; Phan Van Kiem; Bui Huu Tai

doi:10.1002/cbdv.202401787

Suaedamas A-D: Four New Compounds from the Aerial Parts of Suaeda maritima with Inhibition of NO Production Activity

Chem Biodivers. 2024 Aug 27:e202401787. doi: 10.1002/cbdv.202401787. Online ahead of print.

Authors

Bui Thi Nha Trang^{1

2}, Bui Thi Mai Anh³, Nguyen Thi Mai³, Nguyen Thi Cuc⁴, Le Thi Huyen⁵, Nhu Thi Hang Nga⁵, Phan Van Kiem^{1

4}, Bui Huu Tai^{1

4}

Affiliations

¹ Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam.
² Hanoi University of Natural Resources and Environment, 41 A Phu Dien, North Tu Liem, Hanoi, 10000, Vietnam.
³ University of Transport and Communications, Hanoi, 10000, Vietnam.
⁴ Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam.
⁵ Faculty of Chemistry, VNU University of Sciences, Vietnam National University, 334 Nguyen Trai, Thanh Xuan, Hanoi, 10000, Vietnam.

PMID: 39189541
DOI: 10.1002/cbdv.202401787

Abstract

Four new compounds, suaedamas A-D (1-4), and seven known ones (5-11) were isolated from the aerial parts of Suaeda maritima. Their chemical structures were evaluated by the IR, HR-ESI-MS, 1D-, and 2D-NMR, experimental and calculated ECD spectra. Compounds 1-6 inhibited nitric oxide production in LPS activated RAW 264.7 cells with IC₅₀ values ranging from 29.3 to 85.5 μM, compared to that of the positive control compound, dexamethasone, which showed IC₅₀ value of 13.4 μM.

Keywords: Amaranthaceae; NO inhibitory activity; Polyacetylene; Suaeda maritime; Suaedama.

Abstract

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