Laser-induced stripping defect for highly selective electrochemical quantification of dopamine: Anti-interference from other catecholamine neurotransmitters

Ni Su; Kuangbing Wang; Xinran Li; Xiankuan Huo; Guobi Chai; Wu Fan; Qingzhao Shi; Mengya Lv; Shusheng Zhang; Jianping Xie; Ronghan Wei; Qidong Zhang; Qiyan Wang

doi:10.1016/j.talanta.2024.126638

Laser-induced stripping defect for highly selective electrochemical quantification of dopamine: Anti-interference from other catecholamine neurotransmitters

Talanta. 2024 Nov 1:279:126638. doi: 10.1016/j.talanta.2024.126638.

Authors

Ni Su¹, Kuangbing Wang², Xinran Li², Xiankuan Huo³, Guobi Chai⁴, Wu Fan³, Qingzhao Shi³, Mengya Lv², Shusheng Zhang⁵, Jianping Xie³, Ronghan Wei⁶, Qidong Zhang⁷, Qiyan Wang⁸

Affiliations

¹ School of Chemistry, Zhengzhou University, Zhengzhou, 450001, China; Food Laboratory of Zhongyuan, Flavor Science Research Center, Zhengzhou University, Zhengzhou, 450001, China.
² School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou, 450001, China.
³ Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, Zhengzhou, 450001, China.
⁴ School of Chemistry, Zhengzhou University, Zhengzhou, 450001, China; Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, Zhengzhou, 450001, China.
⁵ Food Laboratory of Zhongyuan, Flavor Science Research Center, Zhengzhou University, Zhengzhou, 450001, China.
⁶ School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou, 450001, China; Engineering Technology Research Center of Henan Province for MEMS Manufacturing and Application, Zhengzhou University, Zhengzhou, 450001, China. Electronic address: profwei@zzu.edu.cn.
⁷ School of Chemistry, Zhengzhou University, Zhengzhou, 450001, China; Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, Zhengzhou, 450001, China. Electronic address: qdzhangcn@163.com.
⁸ School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou, 450001, China; Engineering Technology Research Center of Henan Province for MEMS Manufacturing and Application, Zhengzhou University, Zhengzhou, 450001, China. Electronic address: wangqiyan@zzu.edu.cn.

PMID: 39210548
DOI: 10.1016/j.talanta.2024.126638

Abstract

Detecting dopamine (DA) is critical for early diagnosis of neurological and psychiatric disorders. However, the presence of other catecholamine neurotransmitters with structural similarities to DA causes significant interference in its detection. Herein, we introduce S stripping defects via laser-induced MoS₂ to functionalize MoS₂ electrodes and improve their selectivity for DA electrochemical detection. The sensing results show its excellent immunity to interference from other neurotransmitters, ensuring the preservation of the DA electrochemical signal even in the mixed neurotransmitters such as acetylcholine (ACh), γ-aminobutyric acid (GABA), epinephrine (EP), norepinephrine (NP), and serotonin (5-HT). DFT calculations further reveal that the negatively charged S-stripping defects enhance DA adsorption on the surface of the functionalized MoS₂ electrode, contributing to its excellent performance. Moreover, this functionalized electrodes successfully monitor DA released from living PC12 cells in the presence of other interference, highlighting its potential applicability in intercellular signaling communication.

Keywords: Anti-interference; Dopamine; Electrochemical detection; Laser-induced; Living cells; Stripping-defective MoS(2).

MeSH terms

Animals
Catecholamines / analysis
Density Functional Theory
Disulfides / chemistry
Dopamine* / analysis
Electrochemical Techniques* / methods
Electrodes*
Epinephrine / analysis
Lasers*
Molybdenum
Neurotransmitter Agents* / analysis
Norepinephrine / analysis
PC12 Cells
Rats

Substances

Dopamine
Neurotransmitter Agents
Disulfides
molybdenum disulfide
Catecholamines
Epinephrine
Norepinephrine
Molybdenum