Myosin-Inhibitor Mavacamten Acutely Enhances Cardiomyocyte Diastolic Compliance in Heart Failure With Preserved Ejection Fraction

Circ Heart Fail. 2024 Oct;17(10):e011833. doi: 10.1161/CIRCHEARTFAILURE.124.011833. Epub 2024 Sep 6.
No abstract available

Keywords: compliance; heart failure, diastolic; myocardium; myosins; sarcomeres; ventricular dysfunction, left.

Publication types

  • Letter

MeSH terms

  • Animals
  • Benzylamines
  • Compliance
  • Diastole
  • Heart Failure* / drug therapy
  • Heart Failure* / physiopathology
  • Humans
  • Male
  • Myocytes, Cardiac* / drug effects
  • Stroke Volume* / drug effects
  • Stroke Volume* / physiology
  • Uracil / analogs & derivatives
  • Uracil / pharmacology
  • Uracil / therapeutic use
  • Ventricular Function, Left / drug effects

Substances

  • MYK-461
  • Uracil
  • Benzylamines