Vaccine Development Should Be Polytheistic, Not Monotheistic

Stanley A Plotkin; James M Robinson; Joseph R A Fitchett; Edward Gershburg

doi:10.1093/cid/ciae460

Vaccine Development Should Be Polytheistic, Not Monotheistic

Clin Infect Dis. 2024 Sep 6:ciae460. doi: 10.1093/cid/ciae460. Online ahead of print.

Authors

Stanley A Plotkin¹, James M Robinson², Joseph R A Fitchett³, Edward Gershburg⁴

Affiliations

¹ University of Pennsylvania and Vaxconsult, 4650 Wismer Rd, Doylestown PA, USA.
² Independent consultant, 1404 Golden Lake Loop, St Augustine FL, USA.
³ Institut Pasteur de Dakar, 36 Avenue Pasteur, Dakar, Senegal.
⁴ SETA Consulting, 207 Keystone Drive, Chatham IL, USA.

PMID: 39240717
DOI: 10.1093/cid/ciae460

Abstract

Vaccines based on mRNA technology have been tremendously successful, but their properties are not necessarily ideal for all pathogens. There is a risk that concentration on that technology alone for new vaccine development will ignore older technologies that have properties giving broader and more persistent protection.

Keywords: immune responses; mRNA technology; vaccine development.

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