Successful embolization with subsequent pancreaticoduodenectomy for intraductal papillary mucinous neoplasm hemorrhage: a case report and review of literature

Clin J Gastroenterol. 2024 Dec;17(6):1118-1124. doi: 10.1007/s12328-024-02035-5. Epub 2024 Sep 10.

Abstract

Although various complications associated with intraductal papillary mucinous neoplasms have been reported, including acute pancreatitis, duct perforation, and fistula formation, spontaneous bleeding, especially life-threatening bleeding, is infrequent. In this case, emergency pancreatic resection might be one of the therapeutic options, which is associated with poor postoperative outcomes. An 87-year-old woman presented to our hospital with severe anemia (hemoglobin, 4.5 g/dl). Contrast-enhanced computed tomography revealed a large cystic lesion in the pancreatic head measuring 15 cm, with some solid components and an adjacent hematoma, suggestive of intra-cystic hemorrhage of the intraductal papillary mucinous neoplasm. The patient was hemodynamically unstable and had hypotension. After transcatheter arterial embolization, the patient became hemodynamically stable. Subsequently, an elective pylorus-preserving pancreaticoduodenectomy was successfully performed. Preoperative embolization was effective for subsequent elective pancreaticoduodenectomy in patients with severe intraductal papillary mucinous neoplasm bleeding.

Keywords: Hemorrhage; Intraductal papillary mucinous neoplasm; Preoperative embolization; Pylorus-preserving pancreaticoduodenectomy.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adenocarcinoma, Mucinous / complications
  • Adenocarcinoma, Mucinous / surgery
  • Adenocarcinoma, Mucinous / therapy
  • Aged, 80 and over
  • Carcinoma, Pancreatic Ductal / complications
  • Carcinoma, Pancreatic Ductal / surgery
  • Carcinoma, Pancreatic Ductal / therapy
  • Embolization, Therapeutic* / methods
  • Female
  • Hemorrhage / etiology
  • Hemorrhage / therapy
  • Humans
  • Pancreatic Intraductal Neoplasms / complications
  • Pancreatic Intraductal Neoplasms / surgery
  • Pancreatic Neoplasms* / complications
  • Pancreatic Neoplasms* / surgery
  • Pancreaticoduodenectomy*
  • Tomography, X-Ray Computed