Preliminary development of a risk predictor for severe complication in patients with anorexia nervosa

Toshiyuki Shirai; Takaki Tanifuji; Ikuo Otsuka; Satoshi Okazaki; Tadasu Horai; Naruhisa Yamaki; Haruka Minami; Masao Miyachi; Shohei Okada; Akitoyo Hishimoto

doi:10.1016/j.psychres.2024.116151

Preliminary development of a risk predictor for severe complication in patients with anorexia nervosa

Psychiatry Res. 2024 Sep 4:342:116151. doi: 10.1016/j.psychres.2024.116151. Online ahead of print.

Affiliations

¹ Department of Psychiatry, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
² Department of Psychiatry, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan. Electronic address: otsuka19@med.kobe-u.ac.jp.

PMID: 39260070
DOI: 10.1016/j.psychres.2024.116151

Abstract

Anorexia nervosa (AN) is life-threatening because of many physical complications, hence a quantitative indicator for early therapeutic intervention through hospitalization is needed. Here, we compared the demographics of 21 patients with AN who required intensive treatment in the internal medicine ward and those of 61 patients with AN who directly admitted to the psychiatric ward. We developed a risk score for severe physical complications in patients with AN, by using six items with significant differences between two groups; body mass index, blood urea nitrogen, corrected calcium, albumin, aspartate transaminase, and C-reactive protein (area under the curve = 0.824).

Keywords: Anorexia nervosa; Eating disorder; Hospitalization; Physical complications; Risk score.