The expanding universe of type I regulatory T cell biology: a new role in cancer immunotherapy

Immunol Cell Biol. 2024 Nov;102(10):868-870. doi: 10.1111/imcb.12822. Epub 2024 Sep 11.

Abstract

In this article, we discuss new findings which suggest that type I regulatory T (Tr1) cells can interfere with cancer vaccine efficacy in mice by exerting strong regulatory control over antitumor immune responses.

Keywords: Antitumor immune responses; Tr1 cells; cancer immunotherapy; vaccines.

MeSH terms

  • Animals
  • Cancer Vaccines* / immunology
  • Humans
  • Immunotherapy* / methods
  • Mice
  • Neoplasms* / immunology
  • Neoplasms* / therapy
  • T-Lymphocytes, Regulatory* / immunology

Substances

  • Cancer Vaccines