Collaboration between DELLA and MED15 to regulate transcription in plants

Poonam Panchal; Rashmi Ranjan Sutar; Rekha Agrawal; Jitendra K Thakur

doi:10.1093/jxb/erae393

Collaboration between DELLA and MED15 to regulate transcription in plants

J Exp Bot. 2024 Sep 12:erae393. doi: 10.1093/jxb/erae393. Online ahead of print.

Authors

Poonam Panchal¹, Rashmi Ranjan Sutar¹, Rekha Agrawal¹, Jitendra K Thakur¹

Affiliation

¹ International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India.

PMID: 39269757
DOI: 10.1093/jxb/erae393

Abstract

Gibberellins (GA) are diterpenoids that are categorized as one of main hormones that promote major developmental responses such as germination and stem elongation in plants. DELLA proteins act as the key repressors of GA responses. They interact with hundreds of different proteins. While the functioning of DELLA as transcriptional coactivators has also been reported earlier, the actual mechanism still remains elusive. One recent report describes interaction of DELLA with Mediator subunit MED15 as one of the mechanisms contributing to its transcription activation capability (Hernández-García et al. 2024). Interestingly, this mechanism of DELLA-MED15 module-mediated transcription regulation seems to be very ancient conserved from bryophyte Marchantia polymorpha to dicot Arabidopsis thaliana.

Keywords: Arabidopsis; Coactivators; DELLA; Mediator; Transcription factors.