Nontuberculous mycobacteria are a ubiquitous species of bacteria that can produce chronic pulmonary infectious disease in humans. The clinical manifestations are diverse, from an indolent solitary pulmonary nodule up to fibrocavitary disease which carries a poor prognosis. The presentation as a solitary pulmonary nodule has been described in slowly growing mycobacteria, mainly Mycobacterium avium complex and Mycobacterium kansasii. In the following clinical case, we report an infection by a nontuberculous mycobacteria presenting as a solitary pulmonary nodule caused by Mycobacterium abscessus and its outcomes after surgical resection.