Prognostic analysis of appendectomy versus right hemicolectomy for T1 appendiceal adenocarcinoma: a multicenter retrospective analysis

Sci Rep. 2024 Sep 14;14(1):21503. doi: 10.1038/s41598-024-72625-3.

Abstract

Background and aim: Appendiceal adenocarcinoma, an exceedingly rare malignancy, sparks debate on the optimal surgical approach-appendectomy or right hemicolectomy-for early-stage cases. This study aims to investigate the impact of these two surgical methods on the survival prognosis of patients with early appendiceal adenocarcinoma.

Method: Utilizing a multicenter medical database, we gathered data from 168 patients diagnosed with T1 stage appendiceal adenocarcinoma admitted between January 2008 and January 2015. This study aims to compare the impact of different treatment modalities on the prognosis of appendiceal adenocarcinoma in these two groups.

Result: In patients diagnosed with T1 appendiceal adenocarcinoma, the survival prognosis was not significantly improved with right hemicolectomy compared to appendectomy. Out of one hundred twenty-seven patients undergoing right colon resection, only three exhibited lymphatic metastasis, resulting in a rate of 2.3%.

Conclusion: Simple appendectomy can fulfill the objective of achieving radical tumor resection, rendering right hemicolectomy unnecessary.

Keywords: Surgical approach; Survival prognosis; T1 appendiceal adenocarcinoma.

Publication types

  • Multicenter Study
  • Comparative Study

MeSH terms

  • Adenocarcinoma* / mortality
  • Adenocarcinoma* / pathology
  • Adenocarcinoma* / surgery
  • Adult
  • Aged
  • Aged, 80 and over
  • Appendectomy* / methods
  • Appendiceal Neoplasms* / mortality
  • Appendiceal Neoplasms* / pathology
  • Appendiceal Neoplasms* / surgery
  • Colectomy* / methods
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Prognosis
  • Retrospective Studies