A phase I study of MAGE-A1-targeted T1367 T-cell receptor-based cell therapy in patients with advanced multiple myeloma

Josefine Krüger; Matthias Obenaus; Igor Wolfgang Blau; Dana Hoser; Martin Vaegler; Hana Rauschenbach; Ioannis Anagnostopoulos; Korinna Jöhrens; Vivian Scheuplein; Elisa Kieback; Judith Böhme; Ann-Christin Von Brünneck; Jan Krönke; Antonia Busse; Gerald Willimsky; Thomas Blankenstein; Antonio Pezzutto; Ulrich Keller; Axel Nogai

doi:10.3324/haematol.2024.286124

A phase I study of MAGE-A1-targeted T1367 T-cell receptor-based cell therapy in patients with advanced multiple myeloma

Haematologica. 2024 Sep 12. doi: 10.3324/haematol.2024.286124. Online ahead of print.

Authors

Josefine Krüger¹, Matthias Obenaus¹, Igor Wolfgang Blau², Dana Hoser³, Martin Vaegler⁴, Hana Rauschenbach⁴, Ioannis Anagnostopoulos⁵, Korinna Jöhrens⁵, Vivian Scheuplein⁶, Elisa Kieback⁶, Judith Böhme⁵, Ann-Christin Von Brünneck⁵, Jan Krönke⁷, Antonia Busse⁸, Gerald Willimsky⁹, Thomas Blankenstein⁶, Antonio Pezzutto¹⁰, Ulrich Keller¹¹, Axel Nogai¹²

Affiliations

¹ Department of Hematology, Oncology and Cancer Immunology, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin.
² Department of Hematology, Oncology and Cancer Immunology, Campus Virchow Klinikum, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 13353 Berlin.
³ Institute of Immunology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin.
⁴ Experimental and Clinical Research Center, Zellkulturlabor für Klinische Prüfung ZKP, Charité-Universitätsmedizin Berlin, Campus Berlin Buch, 13125 Berlin.
⁵ Institute of Pathology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin.
⁶ Max-Delbrück-Center for Molecular Medicine, 13125 Berlin.
⁷ Department of Hematology, Oncology and Cancer Immunology, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin; German Cancer Consortium (DKTK), partner site Berlin, a partnership between German Cancer Research Center (DKFZ) and Charité-Universitätsmedizin Berlin, 12203 Berlin.
⁸ Department of Hematology, Oncology and Cancer Immunology, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin; Max-Delbrück-Center for Molecular Medicine, 13125 Berlin, Germany; German Cancer Consortium (DKTK), partner site Berlin, a partnership between German Cancer Research Center (DKFZ) and Charité-Universitätsmedizin Berlin, 12203 Berlin.
⁹ Institute of Immunology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany; German Cancer Consortium (DKTK), partner site Berlin, a partnership between German Cancer Research Center (DKFZ) and Charité-Universitätsmedizin Berlin, 12203 Berlin, Germany; German Cancer Research Center (DKFZ), 69120 Heidelberg.
¹⁰ Department of Hematology, Oncology and Cancer Immunology, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin; Max-Delbrück-Center for Molecular Medicine, 13125 Berlin.
¹¹ Department of Hematology, Oncology and Cancer Immunology, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin; Max-Delbrück-Center for Molecular Medicine, 13125 Berlin, Germany; German Cancer Consortium (DKTK), partner site Berlin, a partnership between German Cancer Research Center (DKFZ) and Charité-Universitätsmedizin Berlin, 12203 Berlin. ulrich.keller@charite.de.
¹² Department of Hematology, Oncology and Cancer Immunology, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin. nogai@onkologie-tiergarten.de.

PMID: 39279443
DOI: 10.3324/haematol.2024.286124

Abstract

Not available.