Abstract
Two three-generation families from Northern Sweden with rheumatoid arthritis (RA) were clinically examined. Tissue typing was performed for HLA-A, -B, -C, and -DR antigens. No disease-associated haplotype could be defined within these families. Six of nine members with RA were HLA-DR4 positive. Both families had a HLA-DR4 containing haplotype in the first generation and second-generation members married DR4 positive individuals, which probably increased the risk to develop RA in the third-generation members.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Arthritis, Rheumatoid / genetics
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Arthritis, Rheumatoid / immunology*
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Cells, Cultured
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Female
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Genes, MHC Class II
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Genotype
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HLA Antigens / genetics*
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HLA-A Antigens
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HLA-B Antigens
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HLA-C Antigens
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HLA-DR Antigens
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Histocompatibility Antigens Class II / analysis
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Humans
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Lymphocytes / cytology
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Lymphocytes / immunology
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Male
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Middle Aged
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Pedigree
Substances
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HLA Antigens
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HLA-A Antigens
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HLA-B Antigens
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HLA-C Antigens
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HLA-DR Antigens
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Histocompatibility Antigens Class II