Chalcone derived bis-organosilane and its magnetic nanoparticles: Unveiling precision in selective Cu(II) ion detection and elucidating biocompatibility

Spectrochim Acta A Mol Biomol Spectrosc. 2025 Jan 15:325:125124. doi: 10.1016/j.saa.2024.125124. Epub 2024 Sep 11.

Abstract

The escalating concern regarding the adverse effects of metal ion toxicity on both human health and environmental ecosystems necessitates the development of efficient detection methodologies. This study presents a focused investigation on the selective and sensitive detection of Cu(II) ions employing hybrid magnetic nanoparticles derived from chalcone-based bis-organosilane. These nanoparticles exhibit a notably low detection limit in the nano-scale range, rendering the sensor highly sensitive to Copper(II) ion detection while maintaining robust anti-interference capabilities, even in the presence of diverse metal ions. Real sample analysis confirms the sensor's efficacy in detecting Cu(II) ions below WHO-prescribed levels. Computational analyses reveal molecular interactions and biological activities, including potent antibacterial and antioxidant properties, suggesting promising applications. Furthermore, the biological effectiveness of chalcone-derived bis-organosilane is investigated, unveiling notable antibacterial efficacy and also exhibiting potential as a scavenger of free radicals, indicating promising applications in both antibacterial and antioxidant domains.

Keywords: Antibacterial; Antioxidant; Bis-organosilane; Chalcone; Cu(II) ion; Hybrid magnetic nanoparticles.

MeSH terms

  • Anti-Bacterial Agents* / analysis
  • Anti-Bacterial Agents* / chemistry
  • Anti-Bacterial Agents* / pharmacology
  • Antioxidants / analysis
  • Antioxidants / chemistry
  • Antioxidants / pharmacology
  • Biocompatible Materials / chemistry
  • Biocompatible Materials / pharmacology
  • Chalcone / chemistry
  • Chalcone / pharmacology
  • Copper* / analysis
  • Copper* / chemistry
  • Humans
  • Ions / analysis
  • Magnetite Nanoparticles* / chemistry
  • Microbial Sensitivity Tests
  • Silanes* / chemistry

Substances

  • Copper
  • Silanes
  • Magnetite Nanoparticles
  • Anti-Bacterial Agents
  • Antioxidants
  • Chalcone
  • Biocompatible Materials
  • Ions