Obesity hypoventilation syndrome is associated with worse in-hospital outcomes in patients with acute myocardial infarction: A nationwide study

Abdilahi Mohamoud; Nadhem Abdallah; Mohammed Khalid; Talal Almasri; Abdirahman Wardhere; Mahmoud Ismayl

doi:10.1016/j.rmed.2024.107813

Obesity hypoventilation syndrome is associated with worse in-hospital outcomes in patients with acute myocardial infarction: A nationwide study

Respir Med. 2024 Nov-Dec:234:107813. doi: 10.1016/j.rmed.2024.107813. Epub 2024 Sep 21.

Authors

Abdilahi Mohamoud¹, Nadhem Abdallah², Mohammed Khalid², Talal Almasri², Abdirahman Wardhere³, Mahmoud Ismayl⁴

Affiliations

¹ Department of Internal Medicine, Hennepin Healthcare, Minneapolis, MN, USA. Electronic address: Abdilahi.Mohamoud@hcmed.org.
² Department of Internal Medicine, Hennepin Healthcare, Minneapolis, MN, USA.
³ Columbia University Irving Medical Center, New York, NY, USA.
⁴ Division of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.

PMID: 39307478
DOI: 10.1016/j.rmed.2024.107813

Abstract

Background: Obesity hypoventilation syndrome (OHS) is a condition characterized by obesity, daytime hypercapnia, and sleep-disordered breathing. The impact of OHS on outcomes in patients with acute myocardial infarction (AMI) remains poorly understood.

Methods: We conducted a retrospective analysis using data from the National Inpatient Sample (2016-2020) to evaluate the outcomes of patients with OHS admitted for ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI).

Results: Among STEMI and NSTEMI patients, 0.15 % and 0.37 % had OHS, respectively. After adjusting for confounders, OHS was associated with higher odds of in-hospital mortality, cardiac arrest, acute kidney injury, renal replacement therapy, and respiratory failure requiring intubation in NSTEMI patients. In STEMI patients, OHS was associated with higher odds of cardiac arrest, acute kidney injury, and respiratory failure.

Conclusion: OHS is associated with worse clinical outcomes in patients admitted with AMI, particularly in those with NSTEMI.

Keywords: Acute myocardial infarction; Non-ST-Elevation myocardial infarction; Obesity hypoventilation syndrome; ST-Elevation myocardial infarction.

MeSH terms

Acute Kidney Injury* / epidemiology
Acute Kidney Injury* / etiology
Acute Kidney Injury* / mortality
Acute Kidney Injury* / therapy
Aged
Aged, 80 and over
Female
Heart Arrest / complications
Heart Arrest / mortality
Heart Arrest / therapy
Hospital Mortality*
Humans
Male
Middle Aged
Myocardial Infarction* / complications
Myocardial Infarction* / epidemiology
Myocardial Infarction* / mortality
Non-ST Elevated Myocardial Infarction / complications
Non-ST Elevated Myocardial Infarction / mortality
Non-ST Elevated Myocardial Infarction / therapy
Obesity Hypoventilation Syndrome* / complications
Obesity Hypoventilation Syndrome* / therapy
Respiratory Insufficiency* / epidemiology
Respiratory Insufficiency* / etiology
Respiratory Insufficiency* / mortality
Respiratory Insufficiency* / therapy
Retrospective Studies
ST Elevation Myocardial Infarction / complications
ST Elevation Myocardial Infarction / epidemiology
ST Elevation Myocardial Infarction / mortality
ST Elevation Myocardial Infarction / therapy