Valorization of levulinic acid by esterification with 1-octanol using a novel biocatalyst derived from Araujia sericifera

J Biotechnol. 2024 Nov 20:395:100-109. doi: 10.1016/j.jbiotec.2024.09.014. Epub 2024 Sep 25.

Abstract

Levulinic acid, which can be obtained from biomass, has sparked great interest as a biologically-based chemical building block with wide versatility and potential. Its esterification with alcohols of different chain lengths is a promising valorization process for obtaining esters with various applications in the areas of biofuels/biolubricants, food and cosmetics, among others. In this work, the enzymatic esterification of levulinic acid and 1-octanol using a biocatalyst derived from Araujia sericifera latex was studied in systems with and without solvent. The influence of the molar ratio between alcohol and acid (ranging from 2:1-1:9), the biocatalyst loading (between 7.5 % and 17.5 % relative to the acid), the volume of n-heptane used as reaction solvent (from 0 to 4 ml), and the reaction time (6 hours) were investigated. The activity and stability of the biocatalyst in successive uses were also analyzed. A conversion of 49 % was achieved when the reaction was carried out in a solvent-free system, using an alcohol/acid molar ratio of 1:7 and after 5 h of reaction. On the other hand, the conversion was 65.1 % when the reaction was conducted in a system containing 1 ml of n-heptane as solvent, an alcohol/acid molar ratio of 1:8, and 5 h of reaction. In both cases, a temperature as low as 30 °C and an agitation speed of 300 RPM were used.

Keywords: Araujia sericifera latex; Biocatalysis; Esterification; Levulinic acid; Valorization.

MeSH terms

  • 1-Octanol* / chemistry
  • Biocatalysis
  • Esterification
  • Heptanes / chemistry
  • Latex / chemistry
  • Latex / metabolism
  • Levulinic Acids* / chemistry
  • Levulinic Acids* / metabolism
  • Lipase / chemistry
  • Lipase / metabolism
  • Solvents / chemistry

Substances

  • Levulinic Acids
  • levulinic acid
  • 1-Octanol
  • Heptanes
  • Solvents
  • Lipase
  • Latex
  • n-heptane