Pulmonary alveolar proteinosis: presentation, diagnostic challenges, and management

Br J Hosp Med (Lond). 2024 Sep 30;85(9):1-6. doi: 10.12968/hmed.2024.0250. Epub 2024 Sep 9.

Abstract

Pulmonary alveolar proteinosis is a rare diffuse lung disease; diagnosis and treatment of which is often delayed. We present the case study of a 43-year-old male with a six-month history of worsening breathlessness and non-productive cough referred for specialist respiratory input. Rapid investigations, including high-resolution computed tomography (HRCT) and bronchoalveolar lavage, confirmed the diagnosis of pulmonary alveolar proteinosis. Treatment with whole lung lavage significantly improved pulmonary function and quality of life. We discuss the diagnosis and management of this condition and highlight the importance of early recognition and multidisciplinary teamwork in managing pulmonary alveolar proteinosis.

Keywords: Interstitial lung disease; Pulmonary alveolar proteinosis; Whole lung lavage.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Bronchoalveolar Lavage* / methods
  • Cough / etiology
  • Dyspnea / etiology
  • Humans
  • Male
  • Pulmonary Alveolar Proteinosis* / diagnosis
  • Pulmonary Alveolar Proteinosis* / therapy
  • Tomography, X-Ray Computed*