Copper-Catalyzed Diamination of Alkenes using o-Benzoylhydroxylamines to Access the Four Azaindoline Families

Org Lett. 2024 Oct 18;26(41):8648-8653. doi: 10.1021/acs.orglett.4c02585. Epub 2024 Oct 4.

Abstract

A mild and efficient method for the copper-catalyzed diamination of alkenes is described. In this reaction, o-benzoylhydroxylamine serves as an electrophilic nitrogen source for the regioselective formation of C-N bonds. This transformation provides a novel strategy for synthesizing all four isomeric 2,3-disubstituted azaindoline families and offers a wide substrate scope.