PKM2-G-quadruplex interactions conspire to regulate the cancer transcriptome

Prakash Kharel; Pavel Ivanov

doi:10.1016/j.molcel.2024.09.013

PKM2-G-quadruplex interactions conspire to regulate the cancer transcriptome

Mol Cell. 2024 Oct 3;84(19):3574-3575. doi: 10.1016/j.molcel.2024.09.013.

Authors

Prakash Kharel¹, Pavel Ivanov²

Affiliations

¹ Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
² Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: pivanov@bwh.harvard.edu.

PMID: 39366344
DOI: 10.1016/j.molcel.2024.09.013

Abstract

In this issue of Molecular Cell, Anastasakis et al. describe a novel function of the metabolic enzyme PKM2 as an RNA G-quadruplex binding protein, which could contribute to cancer biology.

Publication types

Comment

MeSH terms

Carrier Proteins* / genetics
Carrier Proteins* / metabolism
G-Quadruplexes*
Gene Expression Regulation, Neoplastic
Humans
Membrane Proteins* / genetics
Membrane Proteins* / metabolism
Neoplasms* / enzymology
Neoplasms* / genetics
Neoplasms* / metabolism
Thyroid Hormone-Binding Proteins*
Thyroid Hormones* / genetics
Thyroid Hormones* / metabolism
Transcriptome*

Substances

Membrane Proteins
Thyroid Hormone-Binding Proteins
Carrier Proteins
Thyroid Hormones