Abstract
Electrochemical grafting of gallic acid with chitosan (EgGC) voltammetrically deposited on a multitude of substrates exhibiting reversible oxidoreduction suitable for sensor construction is reported. A bioreceptor customized from the fragment antigen binding region of SARS-CoV-2 neutralizing antibodies immobilized on an EgGC matrix supported the selective/specific electrochemical signal transduction with respect to different viral loads (femtogram level) of SARS-CoV-2.
MeSH terms
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Antibodies, Neutralizing / chemistry
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Antibodies, Neutralizing / immunology
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Biosensing Techniques
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COVID-19 / virology
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Chitosan* / chemistry
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Electrochemical Techniques*
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Gallic Acid* / chemistry
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Humans
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Oligopeptides / chemistry
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Oxidation-Reduction*
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SARS-CoV-2*
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Spike Glycoprotein, Coronavirus* / chemistry
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Spike Glycoprotein, Coronavirus* / metabolism
Substances
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Gallic Acid
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Spike Glycoprotein, Coronavirus
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Chitosan
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spike protein, SARS-CoV-2
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Oligopeptides
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Antibodies, Neutralizing