Wilson's disease (WD) is a kind of inherited metabolic liver disease in which most patients need lifelong medication to maintain copper homeostasis in the body. Zinc is one of the most commonly used drugs for WD treatment. However, there are currently few high-quality, large-sample, and prospective clinical trials on zinc agent-treated WD. The selection and application of zinc agents are mainly based on patients' clinical phenotype, tolerance to zinc agents, and physicians' experience in treating WD. This article summarizes the application of zinc agents in WD.
威尔逊氏病（WD）是一种遗传代谢性肝病，大多数患者需要终身服药来维持体内铜稳态。锌剂是治疗WD常用的药物之一。然而，目前关于锌剂治疗WD的高质量、大样本、前瞻性的临床试验较少，何时选择、如何应用锌剂治疗WD，主要是根据患者的临床表型、对锌剂的耐受性以及医生的经验来确定。该文就锌剂在WD中的应用进行综述。.