Reassessment of arterial versus venous perfusion of diabetic retinal neovascularization using ultrawide-field fluorescein angiography

Benjamin R Lin; Piero Carletti; Jonathan Yi; Philip J Rosenfeld; Jonathan F Russell

doi:10.1007/s00417-024-06650-3

Reassessment of arterial versus venous perfusion of diabetic retinal neovascularization using ultrawide-field fluorescein angiography

Graefes Arch Clin Exp Ophthalmol. 2024 Oct 8. doi: 10.1007/s00417-024-06650-3. Online ahead of print.

Authors

Benjamin R Lin¹, Piero Carletti¹, Jonathan Yi¹, Philip J Rosenfeld¹, Jonathan F Russell²

Affiliations

¹ Department of Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, USA.
² Department of Ophthalmology and Visual Sciences, University of Iowa, 200 Hawkins Dr, PFP 11196-J, Iowa City, USA. Jonathan-russell@uiowa.edu.

PMID: 39377805
DOI: 10.1007/s00417-024-06650-3

Abstract

Purpose: The purpose of this study was to assess whether diabetic NV is perfused by the arterial or the venous circulation.

Methods: This is a retrospective, consecutive case series evaluating patients with proliferative diabetic retinopathy (PDR) imaged with ultrawide-field (UWF) fluorescein angiography (FA). Areas of neovascularization elsewhere (NVE) and neovascularization of the disc (NVD) were assessed. Perfusion was defined as arterial, arteriovenous, or venous if the area of diabetic neovascularization (NV) began to hyperfluoresce either prior, during, or after laminar venous flow, respectively.

Results: A total of 180 eyes from 176 patients with 928 NV were identified (830 NVE, 98 NVD). Of those, 5.1% of NVE were classified as arterial and 58.2% of NVD were classified as arterial. The remaining NV were classified as arteriovenous except for a small subset (6.1%) which were indeterminate. None of the NV were classified as venous. Noteworthy examples demonstrated NV that nearly fully perfused prior to any detectable fluorescence within nearby veins as well as clear shunting of blood from a feeding artery to a draining vein.

Conclusions: UWF FA images suggest that some NV is perfused by retinal arteries. This may be useful in devising strategies for early detection and treatment of NV precursors.

Key messages: What is known • Diabetic retinal neovascularization has long been thought to be perfused by the retinal venous circulation. • Vascular endothelial growth factor has been shown to play key roles in both angiogenesis and arteriogenesis. What is new • Ultrawide-field fluorescein angiography demonstrates that at least some diabetic neovascularization is perfused by the retinal arterial circulation. • This supports the hypothesis that diabetic neovascularization may arise from arterially-perfused intraretinal microvascular abnormalities in the capillary bed.

Keywords: Arterial perfusion; Diabetic retinopathy; Fluorescein angiography; Neovascularization; Proliferative diabetic retinopathy; Venous perfusion.