Climate change is one of humankind’s biggest challenges, leading to more frequent and intense climate extremes, including heatwaves, wildfires, hurricanes, ocean acidification, and increased extinction rates. Nanotechnology already plays an important role in decarbonizing critical processes. Still, despite the technical advances seen in the last decades, the International Energy Agency has identified many sectors that are not on track to achieve the global climate mitigation goals by 2030. Here, a multi-stakeholder group of nanoscientists from the public, private, and philanthropic sectors discuss four high-potential application spaces where nanotechnologies could accelerate progress: batteries and energy storage; catalysis; coatings, lubricants, membranes, and other interface technology; and capture of greenhouse gases. This comment highlights opportunities and current gaps for those working to minimize the climate crisis and provides a framework for the nanotechnology community to answer the call to action on this global issue.