At its best, the practice of medicine involves careful integration of experience and evidence. Generating evidence to address controversies in radiology - and translating such evidence to practice - requires appropriate selection of methods, and an understanding of the strengths, shortcomings, and biases inherent to different research designs and analyses. Equipped with such knowledge, the radiologic community can ensure that both research and clinical practice in our discipline excels, and that those questions that will be the most critical to answer will be formulated for successful investigation in the years to come.
Keywords: Bias; Evidence; Study design; Test performance.
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