Differences in progressive supranuclear palsy in patients of Asian ancestry?

Shen-Yang Lim; Azalea T Pajo; Alfand Marl F Dy Closas; JiaWei Hor; Tzi Shin Toh; Su Juen Ngim; Yi Zhe Lim; Ai Huey Tan

doi:10.1016/j.parkreldis.2024.107162

Differences in progressive supranuclear palsy in patients of Asian ancestry?

Parkinsonism Relat Disord. 2024 Oct 6:107162. doi: 10.1016/j.parkreldis.2024.107162. Online ahead of print.

Authors

Shen-Yang Lim¹, Azalea T Pajo², Alfand Marl F Dy Closas³, JiaWei Hor², Tzi Shin Toh², Su Juen Ngim⁴, Yi Zhe Lim⁴, Ai Huey Tan²

Affiliations

¹ Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. Electronic address: sylim@ummc.edu.my.
² Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
³ Metro Davao Medical and Research Center, Davao Doctors Hospital, Davao City, Philippines.
⁴ Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

PMID: 39406616
DOI: 10.1016/j.parkreldis.2024.107162

Abstract

Recent studies highlight an over-representation of progressive supranuclear palsy, with atypical features, in South Asians. We offer additional insights, including an over-representation of PSP among Malaysian patients of Indian compared to other Asian ancestries. However, RBD symptoms, hallucinations, and early onset were not more frequent in Indians vs. Chinese.

Publication types

Letter